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In human lymphoma, the transcriptomic remodeling of non-hematopoietic cells has been reported, including the upregulation of CD70 in the medulla stromal cells which drives the accumulation of CD27-positive malignant B cells in the medullary regions (114)

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This modeling strategy enables us to robustly assess the statistical significance of deaths in social proximity while accounting for unobserved spatial and temporal confounders